TTC21B (IFT139 or NPHP12) Antibody

Biological Background

When you need to assess TTC21B with attention to cellular organization, this antibody provides a focused option. TTC21B is a microtubule-organizing element often evaluated in cell-cycle and cilia studies. Its behavior can reflect changes in differentiation state, stress, or remodeling of cellular architecture.

In some datasets and protocols, it is referenced by the gene symbol IFT139.

Use in the Laboratory

Disruption of intraflagellar transport or basal body function can produce distinct localization signatures. Because regulation can be multi-layered, combining abundance and localization information can sharpen conclusions. Kidney disease modeling efforts may include this target when exploring podocyte stress responses and structural change.

Many targets show context-dependent localization, so comparisons across matched conditions can reveal meaningful patterns.

To keep datasets interpretable, labs often document:

• changes in cilia incidence or apparent length in perturbation studies
• signal enrichment at basal bodies versus cytoplasm
• cell-cycle linked differences in localization

Version Notes

This regular format is a practical starting point when you want flexibility across sample types and iterative optimization. If your study compares multiple conditions, keep acquisition and processing settings stable to avoid confounding. Small differences in preparation can reshape apparent localization, so interpret results in context.

If your study spans multiple model systems, it can help to define a shared reference condition for TTC21B so cross-sample contrasts stay meaningful.

The regular format version supports deeper biological narratives around TTC21B without overcomplicating setup.