Triciribine (API-2)

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Selleck Chemicals

S1117-5MG

€144,00 EUR
€144,00 EUR
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Triciribine (API-2) is an inhibitor of AKT and DNA/RNA Synthesis and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs. It is especially relevant in cancer, cell signaling, and dna damage / repair models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control.

By inhibiting AKT and DNA/RNA Synthesis and related targets, Triciribine (API-2) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving AKT and DNA/RNA Synthesis and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Triciribine (API-2) is appropriate when a defined chemical perturbant is needed to connect AKT and DNA/RNA Synthesis and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
AKT • DNA/RNA Synthesis • PI3K
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • DNA Damage Response • Viral Entry / Replication
Research Area:
Cancer • Cell Signaling • DNA Damage / Repair • Infectious Disease
CAS No.:
35943-35-2
Molecular Weight:
320.3
Formula:
C₁₃H₁₆N₆O₄
SMILES:
CN1C2=NC=NC3=C2C(=CN3C4C(C(C(O4)CO)O)O)C(=N1)N
InChIKey:
HOGVTUZUJGHKPL-UHFFFAOYSA-N
PubChem:
65399
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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