TP0463518

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Selleck Chemicals

S0729-2MG

€225,00 EUR
€225,00 EUR
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TP0463518 is an inhibitor of HIF used in studies of pathway modulation. In practice, this places the compound in experiments that measure pathway-dependent signal amplification or attenuation in angiogenesis, cancer, and cell signaling models. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.

By inhibiting HIF, TP0463518 can be used to examine pathway-dependent signal amplification or attenuation. This target class is commonly examined through pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HIF
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies
  • Phenotypic profiling in angiogenesis, cancer, and cell signaling models

Overall, TP0463518 is appropriate when a defined chemical perturbant is needed to connect HIF with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HIF
Target Class:
Signaling Pathway Modulator
Research Area:
Angiogenesis • Cancer • Cell Signaling
CAS No.:
1558021-37-6
Molecular Weight:
431.83
Formula:
C₂₀H₁₈ClN₃O₆
SMILES:
C1CN(C(=O)C(=C1O)C(=O)NCC(=O)O)CC2=CN=C(C=C2)OC3=CC=C(C=C3)Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.