Thalidomide-OH

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Selleck Chemicals

S1015-100MG

€409,00 EUR
€409,00 EUR
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Thalidomide-OH is a modulator of E3 Ligase used in studies of Protein Degradation / Proteasome. It is especially relevant in cancer and protein homeostasis models, where defined compound exposure can be linked to ubiquitin-dependent turnover, proteostasis, and targeted protein degradation.

By modulating E3 Ligase, Thalidomide-OH can be used to examine ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving E3 Ligase
  • Pathway perturbation studies connected to Protein Degradation / Proteasome
  • Context-dependent response profiling and mechanism comparison
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, Thalidomide-OH is appropriate when a defined chemical perturbant is needed to connect E3 Ligase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
E3 Ligase
Target Class:
Enzyme
Pathways:
Protein Degradation / Proteasome
Research Area:
Cancer • Protein Homeostasis
CAS No.:
5054-59-1
Molecular Weight:
274.23
Formula:
C₁₃H₁₀N₂O₅
SMILES:
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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