Tenovin-6

1 1

Selleck Chemicals

S4900-1MG

€206,00 EUR
€206,00 EUR
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Tenovin-6 is an activator of p53 and Sirtuins used in studies of Apoptosis and Epigenetic Regulation and related signaling programs. It is especially relevant in aging, apoptosis, and cancer models, where defined compound exposure can be linked to caspase-associated cell-death signaling and survival decisions and chromatin-state control, histone modification, and transcriptional regulation.

By activating p53 and Sirtuins, Tenovin-6 can be used to examine caspase-associated cell-death signaling and survival decisions and chromatin-state control, histone modification, and transcriptional regulation. This context is compatible with apoptosis, viability, and caspase-readout assays and chromatin, histone-mark, and gene-expression profiling, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In aging, apoptosis, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving p53 and Sirtuins
  • Pathway perturbation studies connected to Apoptosis and Epigenetic Regulation and related signaling programs
  • Gain-of-function pathway-activation studies
  • Phenotypic profiling in aging, apoptosis, and cancer models

Overall, Tenovin-6 is appropriate when a defined chemical perturbant is needed to connect p53 and Sirtuins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in aging, apoptosis, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
p53 • Sirtuins
Target Class:
Other
Pathways:
Apoptosis • Epigenetic Regulation • Metabolic Signaling
Research Area:
Aging • Apoptosis • Cancer • Cell Cycle
CAS No.:
1011557-82-6
Molecular Weight:
454.63
Formula:
C₂₅H₃₄N₄O₂S
SMILES:
CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.