Tandutinib (MLN518)

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Selleck Chemicals

S1043-25MG

€144,00 EUR
€144,00 EUR
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Tandutinib (MLN518) is an inhibitor of FLT3 and PDGFR and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. It is especially relevant in angiogenesis, cancer, and cell signaling models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation.

By inhibiting FLT3 and PDGFR and related targets, Tandutinib (MLN518) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving FLT3 and PDGFR and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Tandutinib (MLN518) is appropriate when a defined chemical perturbant is needed to connect FLT3 and PDGFR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
FLT3 • PDGFR • c-Kit • CSF-1R
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling • Immune Signaling
Research Area:
Angiogenesis • Cancer • Cell Signaling • Immunology
CAS No.:
387867-13-2
Molecular Weight:
562.7
Formula:
C₃₁H₄₂N₆O₄
SMILES:
CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5
InChIKey:
UXXQOJXBIDBUAC-UHFFFAOYSA-N
PubChem:
3038522
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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