TAE226 (NVP-TAE226)

1 1

Selleck Chemicals

S2820-5MG

€167,00 EUR
€167,00 EUR
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TAE226 (NVP-TAE226) is an inhibitor of FAK and c-Met and related targets used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in angiogenesis, apoptosis, and cancer models.

By inhibiting FAK and c-Met and related targets, TAE226 (NVP-TAE226) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving FAK and c-Met and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, TAE226 (NVP-TAE226) is appropriate when a defined chemical perturbant is needed to connect FAK and c-Met and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
FAK • c-Met • IGF-1R • VEGFR1
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • Apoptosis
Research Area:
Angiogenesis • Apoptosis • Cancer • Cell Signaling
CAS No.:
761437-28-9
Molecular Weight:
468.94
Formula:
C₂₃H₂₅ClN₆O₃
SMILES:
CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC
InChIKey:
UYJNQQDJUOUFQJ-UHFFFAOYSA-N
PubChem:
9934347
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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