SMARCC2/BAF170 Antibody

About the Target

SMARCC2, also known as BAF170, plays a central role as part of the BAF (BRG1/BRM-associated factor) complex, a member of the ATP-dependent SWI/SNF-like chromatin remodeling family. In embryonic stem (ES) cells, BAF complexes are crucial for maintaining pluripotency by dynamically regulating gene expression through chromatin remodeling activities. Depending on the literature source, SMARCC2 may also be discussed as SMARCC2/BAF170 and BAF170.

Reported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following SMARCC2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

SMARCC2 is commonly interpreted in the context of developmental biology, stem cell biology, and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• signal enrichment within nucleus relative to the broader cellular background
• stage-dependent patterns during differentiation, morphogenesis, or lineage commitment
• state transitions between self-renewal, priming, and differentiation
• links between target behavior and transcriptional or chromatin-state changes

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for SMARCC2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in SMARCC2 reflect biology rather than handling. When interpreting SMARCC2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep SMARCC2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.