SIS3 Hydrochloride

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Selleck Chemicals

S7959-2MG

€144,00 EUR
€144,00 EUR
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SIS3 Hydrochloride is an inhibitor of TGF-beta / Smad used in studies of MAPK / ERK Signaling and TGF-beta / Smad Signaling. It is especially relevant in cancer, cell signaling, and developmental biology models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and Smad-mediated transcription, differentiation, and fibrotic signaling.

By inhibiting TGF-beta / Smad, SIS3 Hydrochloride can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and Smad-mediated transcription, differentiation, and fibrotic signaling. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TGF-beta / Smad
  • Pathway perturbation studies connected to MAPK / ERK Signaling and TGF-beta / Smad Signaling
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, SIS3 Hydrochloride is appropriate when a defined chemical perturbant is needed to connect TGF-beta / Smad with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TGF-beta / Smad
Target Class:
Signaling Pathway Modulator
Pathways:
MAPK / ERK Signaling • TGF-beta / Smad Signaling
Research Area:
Cancer • Cell Signaling • Developmental Biology
CAS No.:
521984-48-5
Molecular Weight:
489.99
Formula:
C₂₈H₂₇N₃O₃·HCl
SMILES:
CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.