SGI-1776 free base
Selleck Chemicals
SKU:S2198-5MG
Couldn't load pickup availability
SGI-1776 free base is an inhibitor of PIM and FLT3 used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in apoptosis, autophagy, and cancer models.
By inhibiting PIM and FLT3, SGI-1776 free base can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving PIM and FLT3
- Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
- Concentration-response inhibition and target-dependence studies
- Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
Overall, SGI-1776 free base is appropriate when a defined chemical perturbant is needed to connect PIM and FLT3 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- PIM • FLT3
- Target Class:
- Kinase
- Pathways:
- MAPK / ERK Signaling • JAK-STAT Signaling • Cell Cycle Regulation
- Research Area:
- Apoptosis • Autophagy • Cancer • Cell Signaling
- CAS No.:
- 1025065-69-3
- Molecular Weight:
- 405.42
- Formula:
- C₂₀H₂₂F₃N₅O
- SMILES:
- CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
- InChIKey:
- MHXGEROHKGDZGO-UHFFFAOYSA-N
- PubChem:
- 24795070
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
Products may be subject to intellectual property rights.
The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.