Salermide

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Selleck Chemicals

S8460-10MG

€95,00 EUR
€95,00 EUR
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Salermide is an inhibitor of Sirtuins used in studies of DNA Damage Response and Epigenetic Regulation. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation in aging, cancer, and dna damage / repair models.

By inhibiting Sirtuins, Salermide can be used to examine checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In aging, cancer, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Sirtuins
  • Pathway perturbation studies connected to DNA Damage Response and Epigenetic Regulation
  • Concentration-response inhibition and target-dependence studies
  • Chromatin, epigenetic, and gene-expression profiling

Overall, Salermide is appropriate when a defined chemical perturbant is needed to connect Sirtuins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in aging, cancer, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Sirtuins
Target Class:
Epigenetic Regulator
Pathways:
DNA Damage Response • Epigenetic Regulation
Research Area:
Aging • Cancer • DNA Damage / Repair • Epigenetics
CAS No.:
1105698-15-4
Molecular Weight:
394.47
Formula:
C₂₆H₂₂N₂O₂
SMILES:
CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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