Rosiglitazone (BRL 49653)

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Selleck Chemicals

S2556-25MG

€144,00 EUR
€144,00 EUR
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Rosiglitazone (BRL 49653) is an agonist of PPAR and PPAR gamma used in studies of Autophagy and Calcium Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to autophagic flux, lysosomal turnover, and stress adaptation and calcium flux, excitability, and secretion-linked signaling in autophagy, endocrinology, and metabolism models.

By activating PPAR and PPAR gamma, Rosiglitazone (BRL 49653) can be used to examine autophagic flux, lysosomal turnover, and stress adaptation and calcium flux, excitability, and secretion-linked signaling. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In autophagy, endocrinology, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PPAR and PPAR gamma
  • Pathway perturbation studies connected to Autophagy and Calcium Signaling and related signaling programs
  • Agonist-response and downstream signaling studies
  • Reporter-gene, receptor-binding, and transcriptional assays

Overall, Rosiglitazone (BRL 49653) is appropriate when a defined chemical perturbant is needed to connect PPAR and PPAR gamma with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, endocrinology, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PPAR • PPAR gamma
Target Class:
Nuclear Receptor
Pathways:
Autophagy • Calcium Signaling • Hormone Signaling
Research Area:
Autophagy • Endocrinology • Metabolism • Neuroscience
CAS No.:
122320-73-4
Molecular Weight:
357.43
Formula:
C₁₈H₁₉N₃O₃S
SMILES:
CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
InChIKey:
YASAKCUCGLMORW-UHFFFAOYNA-N
PubChem:
77999
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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