R406

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Selleck Chemicals

S2194-5MG

€167,00 EUR
€167,00 EUR
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R406 is an inhibitor of SYK and FLT3 used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in angiogenesis, apoptosis, and cancer models.

By inhibiting SYK and FLT3, R406 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving SYK and FLT3
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, R406 is appropriate when a defined chemical perturbant is needed to connect SYK and FLT3 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
SYK • FLT3
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling • Immune Signaling
Research Area:
Angiogenesis • Apoptosis • Cancer • Cell Signaling
CAS No.:
841290-81-1
Molecular Weight:
628.63
Formula:
C₂₂H₂₃FN₆O₅·C₆H₆O₃S
SMILES:
CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.