R-7050

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Selleck Chemicals

S6643-5MG

€144,00 EUR
€144,00 EUR
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R-7050 is an antagonist of TNF-alpha and Interleukins used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. It is especially relevant in apoptosis, cancer, and immunology models, where defined compound exposure can be linked to cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling.

By blocking TNF-alpha and Interleukins, R-7050 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TNF-alpha and Interleukins
  • Pathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs
  • Receptor-blockade and ligand-competition studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, R-7050 is appropriate when a defined chemical perturbant is needed to connect TNF-alpha and Interleukins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TNF-alpha • Interleukins
Target Class:
Immunomodulator
Pathways:
JAK-STAT Signaling • NF-kB Signaling • Immune Signaling
Research Area:
Apoptosis • Cancer • Immunology • Inflammation
CAS No.:
303997-35-5
Molecular Weight:
380.77
Formula:
C₁₆H₈ClF₃N₄S
SMILES:
C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.