PKI (5-24)
Selleck Chemicals
SKU:E7109-1MG
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PKI (5-24) is an inhibitor of PKA used in studies of GPCR Signaling. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics in cancer and cell signaling models.
By inhibiting PKA, PKI (5-24) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving PKA
- Pathway perturbation studies connected to GPCR Signaling
- Concentration-response inhibition and target-dependence studies
- Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
Overall, PKI (5-24) is appropriate when a defined chemical perturbant is needed to connect PKA with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- PKA
- Target Class:
- Kinase
- Pathways:
- GPCR Signaling
- Research Area:
- Cancer • Cell Signaling
- CAS No.:
- 99534-03-9
- Molecular Weight:
- 2222.38
- Formula:
- C₉₄H₁₄₈N₃₂O₃₁
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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