PIM447 (LGH447)Hydrochloride

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Selleck Chemicals

S7985-2MG

€193,00 EUR
€193,00 EUR
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PIM447 (LGH447)Hydrochloride is an inhibitor of PIM used in studies of JAK-STAT Signaling and Cell Cycle Regulation and related signaling programs. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation and checkpoint control, mitotic progression, and proliferation timing in apoptosis, cancer, and cell signaling models.

By inhibiting PIM, PIM447 (LGH447)Hydrochloride can be used to examine cytokine-responsive transcriptional signaling and immune regulation and checkpoint control, mitotic progression, and proliferation timing. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PIM
  • Pathway perturbation studies connected to JAK-STAT Signaling and Cell Cycle Regulation and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, PIM447 (LGH447)Hydrochloride is appropriate when a defined chemical perturbant is needed to connect PIM with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PIM
Target Class:
Kinase
Pathways:
JAK-STAT Signaling • Cell Cycle Regulation • Apoptosis
Research Area:
Apoptosis • Cancer • Cell Signaling
CAS No.:
1210416-52-6
Molecular Weight:
476.92
Formula:
C₂₄H₂₃F₃N₄O·HCl
SMILES:
CC1CC(CC(C1)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)F
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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