PD 169316

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Selleck Chemicals

S5183-5MG

€144,00 EUR
€144,00 EUR
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PD 169316 is an inhibitor of p38 MAPK and TGF-beta / Smad used in studies of MAPK / ERK Signaling and Immune Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-mediated signaling and inflammatory effector responses in cancer, cell signaling, and developmental biology models.

By inhibiting p38 MAPK and TGF-beta / Smad, PD 169316 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-mediated signaling and inflammatory effector responses. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving p38 MAPK and TGF-beta / Smad
  • Pathway perturbation studies connected to MAPK / ERK Signaling and Immune Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, PD 169316 is appropriate when a defined chemical perturbant is needed to connect p38 MAPK and TGF-beta / Smad with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
p38 MAPK • TGF-beta / Smad
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • Immune Signaling • TGF-beta / Smad Signaling
Research Area:
Cancer • Cell Signaling • Developmental Biology • Inflammation
CAS No.:
152121-53-4
Molecular Weight:
360.34
Formula:
C₂₀H₁₃FN₄O₂
SMILES:
C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)[N+](=O)[O-]
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.