p120-catenin (Ctnnd1) Antibody - FFPE Validated

Biological Background

This antibody supports experimental designs that evaluate p120-catenin with interpretable controls and clear contrasts. p120-catenin is a contact-site protein that shapes barrier properties and signaling at the cell surface. Plan positive and negative controls that match your model system, including perturbations expected to shift the target.

In some datasets and protocols, it is referenced by the gene symbol Ctnnd1.

Use in the Laboratory

Junction proteins are frequently analyzed during differentiation, stress responses, and changes in cell polarity. Time course design can be decisive when regulation is transient or compartment dependent.

Many targets show context-dependent localization, so comparisons across matched conditions can reveal meaningful patterns.

To keep datasets interpretable, labs often document:

• co-localization patterns with cytoskeletal elements
• changes in complex assembly with scaffold or adaptor proteins
• subcellular redistribution at contact sites versus cytoplasm

Version Notes

In sectioned tissue workflows, interpretation often depends on morphology; this format supports that style of readout. If your study compares multiple conditions, keep acquisition and processing settings stable to avoid confounding. Predefine decision rules for excluding outliers so analysis remains transparent.

For challenging targets, pairing p120-catenin measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

For challenging targets, pairing p120-catenin measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

Integrate the fixed-section version into your design so p120-catenin signals can be interpreted alongside matched controls.