NSC 42834

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Selleck Chemicals

S6524-2MG

€95,00 EUR
€95,00 EUR
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NSC 42834 is an inhibitor of JAK2 used in studies of JAK-STAT Signaling. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation in cancer, cell signaling, and immunology models.

By inhibiting JAK2, NSC 42834 can be used to examine cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving JAK2
  • Pathway perturbation studies connected to JAK-STAT Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, NSC 42834 is appropriate when a defined chemical perturbant is needed to connect JAK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
JAK2
Target Class:
Kinase
Pathways:
JAK-STAT Signaling
Research Area:
Cancer • Cell Signaling • Immunology • Inflammation
CAS No.:
195371-52-9
Molecular Weight:
344.45
Formula:
C₂₃H₂₄N₂O
SMILES:
CC(CCC1=CC=CC=N1)(CCC2=CC=CC=N2)C(=O)C3=CC=CC=C3
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.