Motixafortide (BL-8040, BKT140)

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Selleck Chemicals

S9665-5MG

€409,00 EUR
€409,00 EUR
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Motixafortide (BL-8040, BKT140) is an antagonist of CXCR and BCL-2 and related targets used in studies of MAPK / ERK Signaling and Immune Signaling and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-mediated signaling and inflammatory effector responses in apoptosis, cancer, and cell signaling models.

By blocking CXCR and BCL-2 and related targets, Motixafortide (BL-8040, BKT140) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-mediated signaling and inflammatory effector responses. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving CXCR and BCL-2 and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and Immune Signaling and related signaling programs
  • Receptor-blockade and ligand-competition studies
  • GPCR pharmacology, ligand-binding, and signaling assays

Overall, Motixafortide (BL-8040, BKT140) is appropriate when a defined chemical perturbant is needed to connect CXCR and BCL-2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
CXCR • BCL-2 • ERK
Target Class:
GPCR
Pathways:
MAPK / ERK Signaling • Immune Signaling • Apoptosis
Research Area:
Apoptosis • Cancer • Cell Signaling • Immunology
CAS No.:
664334-36-5
Molecular Weight:
2159.52
Formula:
C₉₇H₁₄₄FN₃₃O₁₉S₂
SMILES:
C1CC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2C1)CCCCN)CCCCN)CCCNC(=O)N)CC3=CC=C(C=C3)O)NC(=O)C(CC4=CC5=CC=CC=C5C=C4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C6=CC=C(C=C6)F)C(=O)NC(CCCNC(=N)N)C(=O)N)CCCNC(=O)N)CCCNC(=N)N)CC7=CC=C(C=C7)O
InChIKey:
JJVZSYKFCOBILL-UHFFFAOYSA-N
PubChem:
4939
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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