Mitoxantrone Dihydrochloride (NSC 301739)

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Selleck Chemicals

S2485-50MG

€144,00 EUR
€144,00 EUR
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Mitoxantrone Dihydrochloride (NSC 301739) is an inhibitor of Topoisomerase and PKC used in studies of MAPK / ERK Signaling and DNA Damage Response and related signaling programs. It is especially relevant in apoptosis, cancer, and cell signaling models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint activation, DNA repair, and genome-stability control.

By inhibiting Topoisomerase and PKC, Mitoxantrone Dihydrochloride (NSC 301739) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Topoisomerase and PKC
  • Pathway perturbation studies connected to MAPK / ERK Signaling and DNA Damage Response and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, Mitoxantrone Dihydrochloride (NSC 301739) is appropriate when a defined chemical perturbant is needed to connect Topoisomerase and PKC with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Topoisomerase • PKC
Target Class:
Enzyme
Pathways:
MAPK / ERK Signaling • DNA Damage Response • Apoptosis
Research Area:
Apoptosis • Cancer • Cell Signaling • DNA Damage / Repair
CAS No.:
70476-82-3
Molecular Weight:
517.4
Formula:
C₂₂H₂₉ClN₄O₆·2HCl
SMILES:
C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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