LY2109761

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Selleck Chemicals

S2704-5MG

€265,00 EUR
€265,00 EUR
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LY2109761 is an inhibitor of TGF-beta / Smad used in studies of TGF-beta / Smad Signaling and Apoptosis and related signaling programs. In practice, this places the compound in experiments that measure Smad-mediated transcription, differentiation, and fibrotic signaling and caspase-associated cell-death signaling and survival decisions in apoptosis, autophagy, and cancer models.

By inhibiting TGF-beta / Smad, LY2109761 can be used to examine Smad-mediated transcription, differentiation, and fibrotic signaling and caspase-associated cell-death signaling and survival decisions. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TGF-beta / Smad
  • Pathway perturbation studies connected to TGF-beta / Smad Signaling and Apoptosis and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, LY2109761 is appropriate when a defined chemical perturbant is needed to connect TGF-beta / Smad with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TGF-beta / Smad
Target Class:
Signaling Pathway Modulator
Pathways:
TGF-beta / Smad Signaling • Apoptosis • Autophagy
Research Area:
Apoptosis • Autophagy • Cancer • Cell Signaling
CAS No.:
700874-71-1
Molecular Weight:
441.52
Formula:
C₂₆H₂₇N₅O₂
SMILES:
C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.