Leucovorin Calcium Pentahydrate (Folinic acid)

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Selleck Chemicals

S1236-50MG

€144,00 EUR
€144,00 EUR
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Leucovorin Calcium Pentahydrate (Folinic acid) is an inhibitor of DHFR used in studies of DNA Damage Response. It is especially relevant in cancer, dna damage / repair, and metabolism models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control.

By inhibiting DHFR, Leucovorin Calcium Pentahydrate (Folinic acid) can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, dna damage / repair, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving DHFR
  • Pathway perturbation studies connected to DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, Leucovorin Calcium Pentahydrate (Folinic acid) is appropriate when a defined chemical perturbant is needed to connect DHFR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, dna damage / repair, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
DHFR
Target Class:
Enzyme
Pathways:
DNA Damage Response
Research Area:
Cancer • DNA Damage / Repair • Metabolism
CAS No.:
6035-45-6
Molecular Weight:
601.58
Formula:
C₂₀H₃₁CaN₇O₁₂
SMILES:
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2]
Storage Temperature:
4°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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