KU-60019
Selleck Chemicals
SKU:S1570-10MG
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KU-60019 is an inhibitor of ATM and ATR used in studies of DNA Damage Response. It is especially relevant in cancer, cell signaling, and dna damage / repair models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control.
By inhibiting ATM and ATR, KU-60019 can be used to examine checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving ATM and ATR
- Pathway perturbation studies connected to DNA Damage Response
- Concentration-response inhibition and target-dependence studies
- Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
Overall, KU-60019 is appropriate when a defined chemical perturbant is needed to connect ATM and ATR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- ATM • ATR
- Target Class:
- Kinase
- Pathways:
- DNA Damage Response
- Research Area:
- Cancer • Cell Signaling • DNA Damage / Repair
- CAS No.:
- 925701-49-1
- Molecular Weight:
- 547.67
- Formula:
- C₃₀H₃₃N₃O₅S
- SMILES:
- CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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