KIAA0586 (TALPID3) (Human) (C-Terminus) Antibody - FFPE Validated

Biological Background

To connect mechanism with measurement, this antibody lets you characterize KIAA0586 C-Terminus in pathway-driven studies. KIAA0586 C-Terminus is a trafficking-related component that can localize to basal bodies and ciliary axonemes. Many projects interpret this target alongside interacting partners, upstream cues, and downstream readouts.

In some datasets and protocols, it is referenced by the gene symbol TALPID3.

Use in the Laboratory

Disruption of intraflagellar transport or basal body function can produce distinct localization signatures. Considering complex membership and compartment shifts can clarify whether changes reflect signaling or redistribution.

Many targets show context-dependent localization, so comparisons across matched conditions can reveal meaningful patterns.

To keep datasets interpretable, labs often document:

• cell-cycle linked differences in localization
• changes in cilia incidence or apparent length in perturbation studies
• co-occurrence with intraflagellar transport markers

Version Notes

This fixed-section oriented version is intended for paraffin-embedded tissue, where crosslinking and retrieval steps can shape epitope accessibility. If your study compares multiple conditions, keep acquisition and processing settings stable to avoid confounding.

If your study spans multiple model systems, it can help to define a shared reference condition for KIAA0586 C-Terminus so cross-sample contrasts stay meaningful.

For challenging targets, pairing KIAA0586 C-Terminus measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

The fixed-section option supports mechanistic reading of KIAA0586 C-Terminus when interactions and context are the focus.