JK184

1 1

Selleck Chemicals

S6565-5MG

€144,00 EUR
€144,00 EUR
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JK184 is an inhibitor of Hedgehog used in studies of Hedgehog Signaling and GPCR Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to morphogen-dependent developmental signaling and transcriptional patterning and receptor-driven second-messenger signaling and desensitization dynamics in cancer and developmental biology models.

By inhibiting Hedgehog, JK184 can be used to examine morphogen-dependent developmental signaling and transcriptional patterning and receptor-driven second-messenger signaling and desensitization dynamics. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Hedgehog
  • Pathway perturbation studies connected to Hedgehog Signaling and GPCR Signaling
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, JK184 is appropriate when a defined chemical perturbant is needed to connect Hedgehog with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Hedgehog
Target Class:
Signaling Pathway Modulator
Pathways:
Hedgehog Signaling • GPCR Signaling
Research Area:
Cancer • Developmental Biology
CAS No.:
315703-52-7
Molecular Weight:
350.44
Formula:
C₁₉H₁₈N₄OS
SMILES:
CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.