Ivacaftor (VX-770)

1 1

Selleck Chemicals

S1144-5MG

€167,00 EUR
€167,00 EUR
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Ivacaftor (VX-770) is an activator of CFTR used in studies of ion-channel pharmacology. In practice, this places the compound in experiments that measure ion conductance, membrane potential, and electrophysiological responses in cell signaling and endocrinology models.

By activating CFTR, Ivacaftor (VX-770) can be used to examine ion conductance, membrane potential, and electrophysiological responses. This target class is commonly examined through electrophysiology, ion-flux, and membrane-potential studies, together with downstream-response mapping. In cell signaling and endocrinology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving CFTR
  • Gain-of-function pathway-activation studies
  • Electrophysiology, ion-flux, and membrane-potential studies
  • Phenotypic profiling in cell signaling and endocrinology models

Overall, Ivacaftor (VX-770) is appropriate when a defined chemical perturbant is needed to connect CFTR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling and endocrinology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
CFTR
Target Class:
Ion Channel
Research Area:
Cell Signaling • Endocrinology
CAS No.:
873054-44-5
Molecular Weight:
392.49
Formula:
C₂₄H₂₈N₂O₃
SMILES:
CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
InChIKey:
PURKAOJPTOLRMP-UHFFFAOYSA-N
PubChem:
16220172
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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