Integrin alpha-E (ITGAE or CD103) Antibody - FFPE Validated

Scientific Overview

Designed to help you evaluate Integrin alpha-E, this antibody supports studies where protein context matters. Integrin alpha-E is an adhesion-related target that can shift with substrate composition and mechanical cues. Its behavior can reflect changes in differentiation state, stress, or remodeling of cellular architecture.

In some datasets and protocols, it is referenced by the gene symbol ITGAE.

Research Relevance

Perturbations that disrupt integrin engagement or actomyosin tension can reshape localization and complex assembly. Because regulation can be multi-layered, combining abundance and localization information can sharpen conclusions.

Since many cellular processes are coupled, measured differences can reflect both direct regulation and indirect effects from broader state changes.

When building a narrative around the target, it helps to track:

• co-variation with cytoskeletal and scaffold partners
• effects of adhesion inhibitors or matrix composition
• focal adhesion versus diffuse membrane distribution

Application-Specific Context

Because fixation can mask epitopes, fixed-section oriented formats aim to maintain recognition after standard deparaffinization and retrieval steps. Think about how preparation affects epitope accessibility, and interpret patterns alongside morphology and compartment markers as needed.

When interpreting Integrin alpha-E, consider whether changes track with compartment identity, cell density, or perturbation timing; these factors can influence apparent signal without implying a direct causal link.

To support downstream analysis, record key context variables (culture timing, stimulation window, and extraction approach) so Integrin alpha-E patterns can be compared across experiments without guesswork.

The fixed-section version supports deeper biological narratives around Integrin alpha-E without overcomplicating setup.