HO-3867
Selleck Chemicals
SKU:S7501-5MG
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HO-3867 is an inhibitor of STAT used in studies of JAK-STAT Signaling and Apoptosis. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation and caspase-associated cell-death signaling and survival decisions in apoptosis, cancer, and cell signaling models.
By inhibiting STAT, HO-3867 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and caspase-associated cell-death signaling and survival decisions. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving STAT
- Pathway perturbation studies connected to JAK-STAT Signaling and Apoptosis
- Concentration-response inhibition and target-dependence studies
- Pathway-reporter and mechanistic-phenotyping studies
Overall, HO-3867 is appropriate when a defined chemical perturbant is needed to connect STAT with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- STAT
- Target Class:
- Signaling Pathway Modulator
- Pathways:
- JAK-STAT Signaling • Apoptosis
- Research Area:
- Apoptosis • Cancer • Cell Signaling • Immunology
- CAS No.:
- 1172133-28-6
- Molecular Weight:
- 464.55
- Formula:
- C₂₈H₃₀F₂N₂O₂
- SMILES:
- CC1(C=C(C(N1O)(C)C)CN2CC(=CC3=CC=C(C=C3)F)C(=O)C(=CC4=CC=C(C=C4)F)C2)C
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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