GANT 61 (NSC 136476)

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Selleck Chemicals

S8075-10MG

€144,00 EUR
€144,00 EUR
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GANT 61 (NSC 136476) is an inhibitor of Hedgehog used in studies of Wnt Signaling and Hedgehog Signaling and related signaling programs. In practice, this places the compound in experiments that measure beta-catenin-dependent transcription and developmental signaling and morphogen-dependent developmental signaling and transcriptional patterning in apoptosis, autophagy, and cancer models.

By inhibiting Hedgehog, GANT 61 (NSC 136476) can be used to examine beta-catenin-dependent transcription and developmental signaling and morphogen-dependent developmental signaling and transcriptional patterning. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Hedgehog
  • Pathway perturbation studies connected to Wnt Signaling and Hedgehog Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, GANT 61 (NSC 136476) is appropriate when a defined chemical perturbant is needed to connect Hedgehog with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Hedgehog
Target Class:
Signaling Pathway Modulator
Pathways:
Wnt Signaling • Hedgehog Signaling • Apoptosis
Research Area:
Apoptosis • Autophagy • Cancer • Developmental Biology
CAS No.:
500579-04-4
Molecular Weight:
429.6
Formula:
C₂₇H₃₅N₅
SMILES:
CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.