Fedratinib (TG101348)

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Selleck Chemicals

S2736-5MG

€144,00 EUR
€144,00 EUR
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Fedratinib (TG101348) is an inhibitor of JAK2 and RET and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in apoptosis, cancer, and cell signaling models.

By inhibiting JAK2 and RET and related targets, Fedratinib (TG101348) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving JAK2 and RET and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Fedratinib (TG101348) is appropriate when a defined chemical perturbant is needed to connect JAK2 and RET and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
JAK2 • RET • FLT3
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling • Apoptosis
Research Area:
Apoptosis • Cancer • Cell Signaling • Immunology
CAS No.:
936091-26-8
Molecular Weight:
524.68
Formula:
C₂₇H₃₆N₆O₃S
SMILES:
CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4
InChIKey:
JOOXLOJCABQBSG-UHFFFAOYSA-N
PubChem:
16722836
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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