ETP-46464

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Selleck Chemicals

S8050-10MG

€291,00 EUR
€291,00 EUR
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ETP-46464 is an inhibitor of ATR and ATM and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell cycle, and cell signaling models.

By inhibiting ATR and ATM and related targets, ETP-46464 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell cycle, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving ATR and ATM and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, ETP-46464 is appropriate when a defined chemical perturbant is needed to connect ATR and ATM and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell cycle, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
ATR • ATM • p53
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • DNA Damage Response • Apoptosis
Research Area:
Cancer • Cell Cycle • Cell Signaling • DNA Damage / Repair
CAS No.:
1345675-02-6
Molecular Weight:
470.52
Formula:
C₃₀H₂₂N₄O₂
SMILES:
CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3COC2=O)C5=CC6=CC=CC=C6N=C5
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.