DB07268

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Selleck Chemicals

S6740-5MG

€144,00 EUR
€144,00 EUR
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DB07268 is an inhibitor of JNK and CHK1 used in studies of MAPK / ERK Signaling and DNA Damage Response and related signaling programs. It is especially relevant in cancer, cell cycle, and cell signaling models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint activation, DNA repair, and genome-stability control.

By inhibiting JNK and CHK1, DB07268 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell cycle, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving JNK and CHK1
  • Pathway perturbation studies connected to MAPK / ERK Signaling and DNA Damage Response and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, DB07268 is appropriate when a defined chemical perturbant is needed to connect JNK and CHK1 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell cycle, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
JNK • CHK1
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • DNA Damage Response • Cell Cycle Regulation
Research Area:
Cancer • Cell Cycle • Cell Signaling • DNA Damage / Repair
CAS No.:
929007-72-7
Molecular Weight:
321.33
Formula:
C₁₇H₁₅N₅O₂
SMILES:
C1=CC=C(C(=C1)C(=O)N)NC2=NC(=NC=C2)NC3=CC(=CC=C3)O
InChIKey:
QHPKKGUGRGRSGA-UHFFFAOYSA-N
PubChem:
16058637
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.