CUDC-101

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Selleck Chemicals

S1194-10MG

€223,00 EUR
€223,00 EUR
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CUDC-101 is an inhibitor of HDAC and EGFR and related targets used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer, cell signaling, and epigenetics models.

By inhibiting HDAC and EGFR and related targets, CUDC-101 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and epigenetics models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HDAC and EGFR and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, CUDC-101 is appropriate when a defined chemical perturbant is needed to connect HDAC and EGFR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and epigenetics models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HDAC • EGFR • HER2
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • Epigenetic Regulation
Research Area:
Cancer • Cell Signaling • Epigenetics
CAS No.:
1012054-59-9
Molecular Weight:
434.49
Formula:
C₂₄H₂₆N₄O₄
SMILES:
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
InChIKey:
PLIVFNIUGLLCEK-UHFFFAOYSA-N
PubChem:
24756910
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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