CPI-1189

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Selleck Chemicals

S2465-5MG

€95,00 EUR
€95,00 EUR
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CPI-1189 is an inhibitor of TNF-alpha used in studies of MAPK / ERK Signaling and NF-kB Signaling and related signaling programs. It is especially relevant in apoptosis, cancer, and immunology models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and inflammatory transcriptional control and stress-responsive survival signaling.

By inhibiting TNF-alpha, CPI-1189 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TNF-alpha
  • Pathway perturbation studies connected to MAPK / ERK Signaling and NF-kB Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, CPI-1189 is appropriate when a defined chemical perturbant is needed to connect TNF-alpha with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TNF-alpha
Target Class:
Immunomodulator
Pathways:
MAPK / ERK Signaling • NF-kB Signaling • Immune Signaling
Research Area:
Apoptosis • Cancer • Immunology • Inflammation
CAS No.:
183619-38-7
Molecular Weight:
234.29
Formula:
C₁₃H₁₈N₂O₂
SMILES:
CC(=O)NC1=CC=C(C=C1)C(=O)NC(C)(C)C
InChIKey:
DJKNRCWSXSZACF-UHFFFAOYSA-N
PubChem:
151118
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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