CEP89 (CCDC123) Antibody - FFPE Validated

About the Target

This antibody enables you to explore CEP89 with a direct, biology-first readout. CEP89 is a trafficking-related component that can localize to basal bodies and ciliary axonemes. Look for shifts in distribution that track with phenotype changes.

In some datasets and protocols, it is referenced by the gene symbol CCDC123.

Research Context

Disruption of intraflagellar transport or basal body function can produce distinct localization signatures. Pair measurements with orthogonal readouts when interpretation is sensitive to context.

Consider these angles when interpreting target-level changes:

• co-occurrence with intraflagellar transport markers
• changes in cilia incidence or apparent length in perturbation studies
• cell-cycle linked differences in localization
• signal enrichment at basal bodies versus cytoplasm

Variant Considerations

Because fixation can mask epitopes, fixed-section oriented formats aim to maintain recognition after standard deparaffinization and retrieval steps. This matters because epitope exposure and background can vary with preparation and extraction steps. If you compare conditions, keep processing steps uniform to support clean interpretation.

If your study spans multiple model systems, it can help to define a shared reference condition for CEP89 so cross-sample contrasts stay meaningful.

To support downstream analysis, record key context variables (culture timing, stimulation window, and extraction approach) so CEP89 patterns can be compared across experiments without guesswork.

To support downstream analysis, record key context variables (culture timing, stimulation window, and extraction approach) so CEP89 patterns can be compared across experiments without guesswork.

Select the fixed-section version to keep CEP89 interpretation aligned with your workflow goals.