Calcium Folinate

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Selleck Chemicals

S2588-10MG

€144,00 EUR
€144,00 EUR
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Calcium Folinate is an inhibitor of DHFR used in studies of DNA Damage Response. It is especially relevant in cancer, dna damage / repair, and metabolism models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control.

By inhibiting DHFR, Calcium Folinate can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, dna damage / repair, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving DHFR
  • Pathway perturbation studies connected to DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, Calcium Folinate is appropriate when a defined chemical perturbant is needed to connect DHFR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, dna damage / repair, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
DHFR
Target Class:
Enzyme
Pathways:
DNA Damage Response
Research Area:
Cancer • DNA Damage / Repair • Metabolism
CAS No.:
80433-71-2
Molecular Weight:
511.5
Formula:
C₂₀H₂₁N₇O₇·Ca
SMILES:
[Ca++].NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N2C=O)N1
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.