Bexotegrast (PLN-74809)

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Selleck Chemicals

E1385-5MG

€193,00 EUR
€193,00 EUR
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Bexotegrast (PLN-74809) is an inhibitor of Integrins used in studies of TGF-beta / Smad Signaling. It is especially relevant in angiogenesis, cancer, and developmental biology models, where defined compound exposure can be linked to Smad-mediated transcription, differentiation, and fibrotic signaling.

By inhibiting Integrins, Bexotegrast (PLN-74809) can be used to examine Smad-mediated transcription, differentiation, and fibrotic signaling. This context is compatible with TGF-beta/Smad reporter and transcriptional assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In angiogenesis, cancer, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Integrins
  • Pathway perturbation studies connected to TGF-beta / Smad Signaling
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in angiogenesis, cancer, and developmental biology models

Overall, Bexotegrast (PLN-74809) is appropriate when a defined chemical perturbant is needed to connect Integrins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Integrins
Target Class:
Other
Pathways:
TGF-beta / Smad Signaling
Research Area:
Angiogenesis • Cancer • Developmental Biology
CAS No.:
2376257-44-0
Molecular Weight:
492.61
Formula:
C₂₇H₃₆N₆O₃
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.