AZD6482

1 1

Selleck Chemicals

S1462-5MG

€167,00 EUR
€167,00 EUR
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AZD6482 is an inhibitor of DNA-PK and PI3K beta and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage / repair models.

By inhibiting DNA-PK and PI3K beta and related targets, AZD6482 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving DNA-PK and PI3K beta and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, AZD6482 is appropriate when a defined chemical perturbant is needed to connect DNA-PK and PI3K beta and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
DNA-PK • PI3K beta • PI3K alpha • PI3K delta
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • DNA Damage Response
Research Area:
Cancer • Cell Signaling • DNA Damage / Repair • Immunology
CAS No.:
1173900-33-8
Molecular Weight:
408.45
Formula:
C₂₂H₂₄N₄O₄
SMILES:
CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3C(=O)O)N4CCOCC4
InChIKey:
IRTDIKMSKMREGO-UHFFFAOYSA-N
PubChem:
24836820
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.