Aprepitant

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Selleck Chemicals

S1189-5MG

€167,00 EUR
€167,00 EUR
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Aprepitant is an antagonist of TNF-alpha and Interleukins used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. It is especially relevant in immunology, inflammation, and infectious disease models, where defined compound exposure can be linked to cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling.

By blocking TNF-alpha and Interleukins, Aprepitant can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology, inflammation, and infectious disease models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TNF-alpha and Interleukins
  • Pathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs
  • Receptor-blockade and ligand-competition studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, Aprepitant is appropriate when a defined chemical perturbant is needed to connect TNF-alpha and Interleukins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology, inflammation, and infectious disease models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TNF-alpha • Interleukins
Target Class:
Immunomodulator
Pathways:
JAK-STAT Signaling • NF-kB Signaling • Immune Signaling
Research Area:
Immunology • Inflammation • Infectious Disease • Neuroscience
CAS No.:
170729-80-3
Molecular Weight:
534.43
Formula:
C₂₃H₂₁F₇N₄O₃
SMILES:
CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F
InChIKey:
ATALOFNDEOCMKK-OITMNORJSA-N
PubChem:
6918365
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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