Apilimod (STA-5326)

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Selleck Chemicals

S6414-5MG

€144,00 EUR
€144,00 EUR
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Apilimod (STA-5326) is an inhibitor of Interleukins used in studies of PI3K-Akt-mTOR Signaling and JAK-STAT Signaling and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and cytokine-responsive transcriptional signaling and immune regulation in immunology and inflammation models.

By inhibiting Interleukins, Apilimod (STA-5326) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and cytokine-responsive transcriptional signaling and immune regulation. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Interleukins
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, Apilimod (STA-5326) is appropriate when a defined chemical perturbant is needed to connect Interleukins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Interleukins
Target Class:
Immunomodulator
Pathways:
PI3K-Akt-mTOR Signaling • JAK-STAT Signaling • Immune Signaling
Research Area:
Immunology • Inflammation
CAS No.:
541550-19-0
Molecular Weight:
418.49
Formula:
C₂₃H₂₆N₆O₂
SMILES:
CC1=CC(=CC=C1)C=NNC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4
InChIKey:
HSKAZIJJKRAJAV-UHFFFAOYSA-N
PubChem:
10173277
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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