Ailanthone

1 1

Selleck Chemicals

S6885-1MG

€254,00 EUR
€254,00 EUR
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Ailanthone is an inhibitor of Androgen Receptor and ATM and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in apoptosis, cancer, and cell cycle models.

By inhibiting Androgen Receptor and ATM and related targets, Ailanthone can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Androgen Receptor and ATM and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Ailanthone is appropriate when a defined chemical perturbant is needed to connect Androgen Receptor and ATM and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Androgen Receptor • ATM • ATR • AKT
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • DNA Damage Response • Cell Cycle Regulation
Research Area:
Apoptosis • Cancer • Cell Cycle • Cell Signaling
CAS No.:
981-15-7
Molecular Weight:
376.40
Formula:
C₂₀H₂₄O₇
SMILES:
CC1=CC(=O)C(C2(C1CC3C45C2C(C(C(=C)C4CC(=O)O3)O)(OC5)O)C)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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