A-1155463 Dihydrochloride

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Selleck Chemicals

S7800-5MG

€154,00 EUR
€154,00 EUR
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A-1155463 Dihydrochloride is an inhibitor of BCL-2 used in studies of Apoptosis. It is especially relevant in apoptosis and cancer models, where defined compound exposure can be linked to caspase-associated cell-death signaling and survival decisions.

By inhibiting BCL-2, A-1155463 Dihydrochloride can be used to examine caspase-associated cell-death signaling and survival decisions. This context is compatible with apoptosis, viability, and caspase-readout assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving BCL-2
  • Pathway perturbation studies connected to Apoptosis
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in apoptosis and cancer models

Overall, A-1155463 Dihydrochloride is appropriate when a defined chemical perturbant is needed to connect BCL-2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
BCL-2
Target Class:
Other
Pathways:
Apoptosis
Research Area:
Apoptosis • Cancer
CAS No.:
1235034-55-5 (free base)
Molecular Weight:
742.71
Formula:
C₃₅H₃₄Cl₂FN₅O₄S₂
SMILES:
CN(C)CC#CC1=CC(=C(C=C1)OCCCC2=C(N=C(S2)N3CCC4=C(C3)C(=CC=C4)C(=O)NC5=NC6=CC=CC=C6S5)C(=O)O)F
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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