4-Hydroxytamoxifen (Afimoxifene)

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Selleck Chemicals

S7827-10MG

€144,00 EUR
€144,00 EUR
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4-Hydroxytamoxifen (Afimoxifene) is a modulator of Estrogen Receptor and Estrogen/Progesterone Receptors used in studies of Hormone Signaling. It is especially relevant in cancer and endocrinology models, where defined compound exposure can be linked to ligand-dependent transcriptional programs and endocrine regulation.

By modulating Estrogen Receptor and Estrogen/Progesterone Receptors, 4-Hydroxytamoxifen (Afimoxifene) can be used to examine ligand-dependent transcriptional programs and endocrine regulation. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In cancer and endocrinology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Estrogen Receptor and Estrogen/Progesterone Receptors
  • Pathway perturbation studies connected to Hormone Signaling
  • Context-dependent response profiling and mechanism comparison
  • Reporter-gene, receptor-binding, and transcriptional assays

Overall, 4-Hydroxytamoxifen (Afimoxifene) is appropriate when a defined chemical perturbant is needed to connect Estrogen Receptor and Estrogen/Progesterone Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and endocrinology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Estrogen Receptor • Estrogen/Progesterone Receptors
Target Class:
Nuclear Receptor
Pathways:
Hormone Signaling
Research Area:
Cancer • Endocrinology
CAS No.:
68392-35-8
Molecular Weight:
387.51
Formula:
C₂₆H₂₉NO₂
SMILES:
CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
InChIKey:
TXUZVZSFRXZGTL-OCEACIFDSA-N
PubChem:
449459
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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