{"product_id":"zapnometinib-pd0184264-e0404","title":"Zapnometinib (PD0184264)","description":"\u003cp\u003e\u003cstrong\u003eZapnometinib (PD0184264)\u003c\/strong\u003e is an inhibitor of MEK and ATR used in studies of MAPK \/ ERK Signaling and DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting MEK and ATR, Zapnometinib (PD0184264) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving MEK and ATR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Zapnometinib (PD0184264) is appropriate when a defined chemical perturbant is needed to connect MEK and ATR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804252447065,"sku":"E0404-5MG","price":154.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804252479833,"sku":"E0404-25MG","price":470.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e0404-zapnometinib-chemical-structure.gif?v=1776166003","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/zapnometinib-pd0184264-e0404","provider":"Absource Diagnostics","version":"1.0","type":"link"}