{"product_id":"yap-antibody-sc-f0366","title":"YAP Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eYes-associated protein (YAP or YAP1) is an oncoprotein encoded by the YAP gene located on human chromosome 11q22. It serves as a key downstream effector in the Hippo signaling pathway, working in conjunction with the transcriptional coactivator TAZ (transcriptional coactivator with PDZ-binding motif). YAP and TAZ play critical roles in regulating cell proliferation, regeneration, organ development, and stem cell self-renewal, with their activity modulated by extracellular signals and the cellular microenvironment. Depending on the literature source, YAP may also be discussed as YAP1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell junction, cytoplasm, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following YAP across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eYAP is commonly interpreted in the context of cancer, developmental biology, and stem cell biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell junction, cytoplasm, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell junction, cytoplasm, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003estate transitions between self-renewal, priming, and differentiation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for YAP. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in YAP reflect biology rather than handling. When interpreting YAP, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep YAP trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577447424345,"sku":"F0366-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577447457113,"sku":"F0366-100UL","price":379.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577447489881,"sku":"F0366-2X100UL","price":569.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0366-IHC1.jpg?v=1773598382","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/yap-antibody-sc-f0366","provider":"Absource Diagnostics","version":"1.0","type":"link"}