{"product_id":"wortmannin-sl-2052-s2758","title":"Wortmannin (SL-2052)","description":"\u003cp\u003e\u003cstrong\u003eWortmannin (SL-2052)\u003c\/strong\u003e is an inhibitor of PI3K and ATM and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PI3K and ATM and related targets, Wortmannin (SL-2052) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PI3K and ATM and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Wortmannin (SL-2052) is appropriate when a defined chemical perturbant is needed to connect PI3K and ATM and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805712032089,"sku":"S2758-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"20 mg","offer_id":57805712064857,"sku":"S2758-20MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805712097625,"sku":"S2758-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Wortmannin-chemical-structure-s2758.gif?v=1776175645","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/wortmannin-sl-2052-s2758","provider":"Absource Diagnostics","version":"1.0","type":"link"}