{"product_id":"ube2n-antibody-sc-f1395","title":"UBE2N Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eUBE2N (also known as UBC13) is a K63-ubiquitin-specific E2 conjugating enzyme that plays a critical role in various cellular processes. It forms heterodimers with UBE2V1 (also known as UEV1A) and UBE2V2 (also known as MMS2) to mediate K63-linked polyubiquitination. The UBE2N\/UBE2V1 heterodimer, along with TRAF6 as the E3 ligase, activates the NF-κB and MAPK signaling pathways, essential for immune responses and embryogenesis. Depending on the literature source, UBE2N may also be discussed as UBC13.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and nucleus, which can matter when signal is compared across treatments or changing cell states. Following UBE2N across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eUBE2N is commonly interpreted in the context of inflammation and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for UBE2N. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in UBE2N reflect biology rather than handling. When interpreting UBE2N, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep UBE2N trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577720250713,"sku":"F1395-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577720283481,"sku":"F1395-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577720316249,"sku":"F1395-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1395-wb.gif?v=1773599690","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/ube2n-antibody-sc-f1395","provider":"Absource Diagnostics","version":"1.0","type":"link"}