{"product_id":"tubb3-antibody-sc-f3254","title":"βIII-Tubulin Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eβIII-tubulin, encoded by the TUBB3 gene on chromosome 16q24. 3, is a neuron-specific β-tubulin isotype primarily expressed in the central and peripheral nervous systems and testicular Sertoli cells, with aberrant expression observed in various epithelial cancers. Structurally, it comprises 450 amino acids (or 378 in an alternatively spliced isoform) and features a conserved GTPase domain critical for microtubule dynamics, with a highly divergent C-terminal tail (residues 430-450) that contributes to its isotype-specific functions, including effects on mitochondrial architecture and resistance to paclitaxel-induced apoptosis. Depending on the literature source, TUBB3 may also be discussed as betaIII-Tubulin and TUJ1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell projection, cytoplasm, cytoskeleton, and microtubule, which can matter when signal is compared across treatments or changing cell states. Following TUBB3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTUBB3 is commonly interpreted in the context of cancer, neuroscience, and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell projection, cytoplasm, and cytoskeleton, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell projection, cytoplasm, and cytoskeleton across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TUBB3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TUBB3 reflect biology rather than handling. When interpreting TUBB3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TUBB3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578011754841,"sku":"F3254-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578011787609,"sku":"F3254-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578011820377,"sku":"F3254-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3254-IF.png?v=1773601063","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tubb3-antibody-sc-f3254","provider":"Absource Diagnostics","version":"1.0","type":"link"}