{"product_id":"tuba3-antibody-sc-f3744","title":"Detyrosinated α Tubulin Microtubule Marker Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eTUBA3 is a target of interest in many antibody-based workflows. Detyrosinated α‑tubulin is a microtubule marker and a post‑translationally modified form of α‑tubulin, a structural component of microtubules, which are cytoskeletal filaments formed by polymerization of tubulin proteins. This modification involves the enzymatic removal of the C-terminal tyrosine residue from α‑tubulin by tubulin carboxypeptidases, primarily VASH1 and VASH2 (vasohibins), which function in complex with a small vasohibin‑binding protein (SVBP). Depending on the literature source, TUBA3 may also be discussed as Detyrosinated alpha Tubulin Microtubule Marker and TUBA1A.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoskeleton, and microtubule, which can matter when signal is compared across treatments or changing cell states. Following TUBA3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eTUBA3 is commonly interpreted in the context of neuroscience research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoskeleton, and microtubule, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoskeleton, and microtubule across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for TUBA3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in TUBA3 reflect biology rather than handling. When interpreting TUBA3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep TUBA3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578042392921,"sku":"F3744-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578042425689,"sku":"F3744-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578042458457,"sku":"F3744-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3744-IF.png?v=1773601435","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/tuba3-antibody-sc-f3744","provider":"Absource Diagnostics","version":"1.0","type":"link"}